Oral contraceptives.
Ovarian hypersecretion of androgens can be suppressed with oral contraceptives. Most oral contraceptives contain combinations of estrogens and progestational agents. Oral contraceptives with estrogen (ethynyl estradiol or mestranol) and progestins of low androgenic activity are the most useful. Higher dose estrogen pills are more effective but not as safe.
Most synthetic progesterones have some degree of androgenic activity, which is undesirable in patients who already have signs of androgen excess. Oral contraceptives that appear to be useful in androgenic disorders and acne include Demulen, Ovcon 35, Modicon, Brevicon, and Ortho-Novum 7/7/7. The progesterone ethynodiol diacetate in Demulen is a relatively low androgenic progesterone. Norethindrone is more androgenic, but the low doses contained in Ovcon-35, Modicon, and Brevicon make these pills relatively nonandrogenic. Triphasil, containing levonorgestrel, and Diane (available outside the United States), containing cyproterone acetate, produced a 72% reduction in acne.
The estrogenic and androgenic activity of various oral contraceptives are listed in the Formulary. In many instances acne flares after the use of oral contraceptives is discontinued. Selection of an appropriate agent may provide the benefit of effective acne therapy for women who have chosen an oral contraceptive for birth control. Women in their thirties and forties without risk factors such as smoking or a family history of premature cardiovascular disease can safely use low-dose oral contraceptives to reduce ovarian androgen secretion.
Drugs that may reduce the effectiveness of oral contraceptives
Antibiotics
ampicillin, amoxicillin, isoniazid, metronidazole, penicillin, rifampin, tetracycline
Anticonvulsant drugs
barbiturates, carbamazepine, ethosuximide, phenytoin, primidone
Sedatives and hypnotics
barbiturates, benzodiazepines, chloral hydrate
Others
antacids, antimigraine preparations, clofibrate
Friday, May 23, 2008
Medicine for acne: Oral contraceptives
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9:09 PM
Labels: Antiandrogens, Medicine for acne, Oral contraceptives
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